MDBIE-SMRM Beta — March 28, 2026

Mechanism-Driven Biomedical Intelligence

SHINORIS Engine translates complex biological inputs into structured, evidence-tiered mechanistic analyses — built for researchers, clinicians, and institutions.

Launch EngineLearn More
SMRM v1.0Research-Grade OutputNon-PrescriptiveEvidence Tier Declared
MDBIE Analysis Output — SMRM v1.0
Mechanism
mTOR / AMPK Axis
Pathway
PI3K → Akt → mTORC1
Target
Rapamycin Binding
Established EvidenceSMRM v1.0 · Academic Report
The Platform

Not a chatbot.
A reasoning engine.

SHINORIS Engine (MDBIE) is a subscription-based software platform built for structured biomedical pathway modeling and mechanistic systems analysis. It does not generate conversational responses — it produces organised, evidence-tiered analytical reports grounded in a formal reasoning doctrine.

Where general AI tools produce probabilistic text, SHINORIS applies the Shino Mechanistic Reasoning Model (SMRM v1.0) — a structured cognitive framework that prioritises metabolic safety modeling, pathway convergence mapping, upstream regulator analysis, and explicit uncertainty transparency.

Educational & Research Use Only
Mechanistic Reasoning
Every output traces biological causality through defined pathway logic, not statistical correlation.
Structured Output
Responses are formatted into discrete analytical sections — Mechanism, Pathway, Targets, Notes — not prose paragraphs.
Uncertainty Transparency
Evidence tiers are declared explicitly — Established, Inferred, or Theoretical — so you always know the confidence level.
Core Frameworks

The intellectual architecture
behind the engine.

Two interlocking frameworks define how SHINORIS reasons, structures, and delivers biomedical intelligence.

SMRM
Shino Mechanistic Reasoning Model

SMRM is the cognitive doctrine that governs how SHINORIS processes biological inputs. It enforces a structured reasoning sequence — from upstream regulators to downstream effectors — ensuring every analysis follows causal pathway logic rather than pattern matching.

Upstream regulator identification
Pathway convergence mapping
Metabolic safety modeling
Theoretical layer segregation
Explicit uncertainty declaration
MDBIE
Mechanism-Driven Biomedical Intelligence Engine

MDBIE is the platform layer that operationalises SMRM at scale. It accepts biological variables, compound stacks, or pathway questions and returns multi-format structured reports — from concise executive summaries to full academic-depth analyses.

Multi-format output selection
CYP interaction analysis
Metabolic burden assessment
Evidence tier classification
Non-prescriptive, research-grade output
Process

From query to structured
mechanistic insight.

Five deterministic steps transform a biomedical question into an organised, evidence-tiered analytical report.

01
Input Biomedical Query
Submit biological variables, compound stacks, pathway questions, or protocol requests in natural language. The engine accepts any research-grade biomedical input.
Free-form input
02
Mechanism Analysis
SMRM identifies the primary mechanistic axis — the core biological process or regulatory pathway most relevant to the query — and classifies its evidence tier.
SMRM v1.0
03
Pathway Mapping
The engine traces the full signalling or metabolic pathway — from upstream regulators through effector nodes — constructing a causal map of the biological system.
Causal pathway logic
04
Target Identification
Intervention targets, CYP interactions, metabolic burden points, and theoretical modulators are identified and ranked by evidence strength.
Evidence-tiered
05
Structured Output Delivered
A formatted report is returned — Executive Summary, Academic Report, or Deep Dive — with each section clearly delineated and evidence tiers declared throughout.
Multi-format
Applications

Built for precision work
across disciplines.

SHINORIS serves researchers, clinicians, and institutions who require mechanistic depth that general AI tools cannot provide.

Clinical Reasoning Support
Structured mechanistic analysis to support clinical hypothesis formation and protocol review.
→Pathway-based differential reasoning
→Metabolic interaction mapping
→CYP enzyme interaction analysis
Research Hypothesis Generation
Accelerate hypothesis development with mechanistically grounded pathway analysis and target identification.
→Upstream regulator analysis
→Convergence point identification
→Theoretical layer segregation
Protocol Development
Evaluate compound stacks, intervention sequences, and biological protocols against mechanistic pathway models.
→Compound stack analysis
→Metabolic burden assessment
→Safety modeling (non-prescriptive)
Biomedical Systems Analysis
Map complex multi-pathway interactions and systemic biological relationships with structured, evidence-tiered outputs.
→Multi-pathway interaction modeling
→Regulatory network analysis
→Academic-depth reporting
Differentiation

Precision over probability.

General AI tools generate plausible text. SHINORIS generates mechanistically structured, evidence-tiered biomedical analysis.

CapabilityGeneral AISHINORIS Engine
Mechanistic pathway reasoning✕✓
Structured output sections✕✓
Evidence tier declaration✕✓
CYP interaction analysis✕✓
Metabolic safety modeling✕✓
Theoretical layer segregation✕✓
Formal reasoning doctrine✕✓
General knowledge Q&A✓Not the purpose
5
Structured output sections per analysis
3
Output modes: Executive, Academic, Deep Dive
v1.0
SMRM — the first formal mechanistic reasoning model for biomedical AI
Access Tiers

Research access for every level.

From individual researchers to institutional deployments — structured access to the MDBIE engine at every scale.

Access Tier
Trial
$10CAD / month
Entry-level access to explore the SMRM engine with a limited monthly run allocation.
✓Core SMRM reasoning engine
✓Executive Summary output mode
✓Limited monthly run credits
—Academic Report & Deep Dive modes
—CYP interaction analysis
—Run history & export
Get Started
Access Tier
Casual
$42CAD / month
For occasional users who need structured mechanistic analysis without a full research commitment.
✓Core SMRM reasoning engine
✓Executive Summary output mode
✓Moderate monthly run credits
✓Run history
—Academic Report & Deep Dive modes
—CYP interaction analysis
Get Started
Access Tier
Research
$156CAD / month
Designed for active researchers requiring full output modes and deeper analytical capability.
✓Full SMRM reasoning engine
✓All three output modes
✓Expanded monthly run credits
✓CYP interaction analysis
✓Run history & export
—Multi-user access
Launch Engine
Most Popular
Access Tier
Professional
$356CAD / month
Full engine access for clinicians, advanced researchers, and high-frequency analytical work.
✓Full SMRM reasoning engine
✓All three output modes
✓High monthly run credits
✓CYP interaction analysis
✓Metabolic burden assessment
✓Run history & export
Launch Engine
Access Tier
Institutional
$1,596CAD / month
Enterprise-scale access for research groups, hospitals, and organisations.
✓Everything in Professional
✓Maximum run allocation
✓Multi-user team access
✓Priority model refinement
✓Dedicated onboarding
✓Custom output configuration
Contact for Access

All prices in CAD. Token Bundle top-ups are also available: 100K tokens ($39), 500K tokens ($149), 1M tokens ($249). Early access through the Founding Research Cohort.

Ready to begin

Enter the Engine.

The MDBIE-SMRM beta opens March 28, 2026. Join the Founding Research Cohort and be among the first to access structured biomedical mechanistic intelligence.

Launch Engine

MDBIE is a software platform for educational and research purposes only. It does not provide medical advice, diagnosis, treatment recommendations, or personalised health guidance. This platform models biological mechanisms — not clinical decisions.